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| (Pal M, Krajnc I) Med Mes 2008; 4:94-97 |
Osteoimunologija: RANKL/ RANK/OPG citokinski sistemKoncept osteoimunologije je, da obstajajo povezovalne molekule med skeletnim in imunskim sistemom. Ligand receptorja za aktivator jedrnega dejavnika kapa-B (RANKL), njegov receptor RANK in naravni vabni receptor osteoprotegerin so ključne molekule osteoklastne kostne resorpcije. Pomemben element v osteoimunologiji je inducibilni transkripcijski jedrni dejavnik kapa-B (NF-kapa-B), ki regulira gensko ekspresijo med vnetnimi, imunskimi odgovori ter med osteoklastno diferenciacijo |
Osteoimmunology: RANKL/ RANK/OPG cytokine systemThe concept of osteoimmunology is that certain molecules link the skeletal and immune system. The receptor activator of nuclear factor-kappaB ligand (RANKL), its receptor RANK, and its natural decoy receptor osteoprotegerin have been identified as the final effector molecules of osteoclastic bone resorption. A critical element in osteoimmunology is the inducible transcription factor nuclear factor-kappa-B (NF-kappa-B), which regulates gene expression during inflammatory, immune responses and osteoclast differentiaton. |
Ključne besede:kost, imunologija, kostna remodelacija, ligand receptorja za aktivator jedrnega dejavnika kapa-B (RANKL), osteoprotegerin (OPG) |
Key words:bone, immunology, bone remodeling, receptor activator of nuclear factor kapa-B ligand (RANKL), osteoprotegerin (OPG) |
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